Extended Data Fig. 10: C.-rodentium-induced anti-mitochondrial CD8+ T cells and loss of locomotor function are transient.
From: Intestinal infection triggers Parkinson’s disease-like symptoms in Pink1−/− mice
a, Actimetry tests and grip strength of mice at 12 m.p.i. Data are from a single cohort of mice. b, Quantification of TH+ neurons in the ventral tegmental area after stereological analyses. Data pooled from two independent experiments. c, Representative images of TH staining in the dorsal striatum at 12 m.p.i. Data are from a single cohort. d, Quantification of TH+ neurons in the dorsal and ventral striatum after stereological analyses. Representative of a single cohort. e, Quantification of dopamine transporter (DAT) signal density in the dorsal and ventral striatum at 6 m.p.i. Data accumulated from mice from b. Data pooled from two independent experiments. f, Quantification of OGDH-specific T cells from wild-type and Pink1−/− mice at 13 d.p.i., 6 m.p.i. and 12 m.p.i. Data at 13 d.p.i. are representative of three independent experiments; data at 6 m.p.i. are representative of two independent experiments; data at 12 m.p.i. are from a single cohort of mice. P values determined by two-way ANOVA at a 95% confidence interval with Tukey’s multiple comparison’s test. Data are mean ± s.e.m.
