Extended Data Fig. 8: Quantitative evaluation of AAV genome distribution.
From: A mutation-independent approach for muscular dystrophy via upregulation of a modifier gene
Genomic DNA isolated from the tibialis anterior muscle, sciatic nerve and liver of dy2j/dy2j mice (n = 8) injected with AAVs carrying three guides at the dose of 3 × 1011 viral genomes per gram of mouse (split into two vectors; total dose of 2 × 3 × 1011 viral genomes per gram of mouse) was amplified to analyse the presence of viral genomes by qPCR. Data are mean ± s.e.m. The experiment was repeated three times independently with similar results.
