Extended Data Fig. 9: TCR repertoire of brain homing activated CD4+ T cells in newly diagnosed patients with MS.
From: Opposing T cell responses in experimental autoimmune encephalomyelitis
a, b, Brain homing and activated (CD49d+CD29+HLA-DR+CD38+) CD4+ T cells were single-cell-sorted from PBMCs of healthy controls (a) and newly diagnosed patients with MS (b). The cells underwent single-cell paired TCR sequencing. Pie charts depicting clonal expansion of CD4+ T cells among healthy controls (n = 10) and patients with MS (n = 18). The number of cells with β chain successfully identified is shown above its pie chart. For each TCR clone expressed by two or more cells (clonally expanded), the absolute number of cells expressing that clone (≥2, ≥5, ≥10, ≥20 and ≥50) is shown by a distinct coloured section.
