Extended Data Fig. 1: BORIS is expressed in several cancers and associated with high-risk features.
From: BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells
a, b, Relative mRNA expression [log2(FPKM + 1)] of CTCF and BORIS in normal tissues (a) and in various cancer types based on TCGA datasets (b). FPKM, fragments per kilobase of transcript per million mapped reads. Keys to cancer types: ACC, adrenocortical carcinoma; AML, acute myeloid leukaemia; BLCA, bladder urothelial carcinoma; BRCA, breast invasive carcinoma; CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma; CHOL, cholangiocarcinoma; COAD, colon adenocarcinoma; DLBC, diffuse large B-cell lymphoma; ESCA, oesophageal carcinoma; GBM, glioblastoma multiforme; HNSC, head and neck squamous cell carcinoma; LGG, low-grade glioma; KICH, kidney chromophobe; KIRC, renal clear cell carcinoma; KIRP, kidney renal papillary cell carcinoma; LAML, acute myeloid leukaemia; LIHC, hepatocellular carcinoma; LUAD, lung adenocarcinoma; LUSC, lung squamous cell carcinoma; MESO, mesothelioma; NB, neuroblastoma; OV, serous ovarian cystadenocarcinoma; PAAD, pancreatic adenocarcinoma; PCPG, pheochromocytoma and paraganglioma; PRAD, prostate adenocarcinoma; READ, rectum adenocarcinoma; RT, rhabdoid tumour; SARC, sarcoma; SKCM, skin cutaneous melanoma; STAD, stomach adenocarcinoma; TGCT, testicular germ cell tumour; THCA, thyroid carcinoma; THYM, thymoma; UCEC, uterine corpus endometrial carcinoma; UCS, uterine carcinosarcoma; UVM, uveal melanoma; WT, Wilms tumour. c, Box plots showing the correlation of BORIS expression with risk status, tumour stage (primary versus metastasis/recurrence), presence of cancer stem cells (CD133 positivity) and response to targeted (lapatinib) or cytotoxic (cisplatin) therapy in the tumour types depicted. NSCLC, non-small cell lung cancer. Datasets (Mixed Ewing Sarcoma-Savola-117 and NSCLC-Plamadeala-410) were extracted from the R2: Genomics Analysis and Visualization Platform (http://r2.amc.nl). GSE7181 (glioblastoma); GSE16179 (breast cancer); GSE15372 (ovarian cancer). P values determined by two-sided Wilcoxon rank-sum test. For all panels, sample sizes (n) are depicted in parenthesis and box plots are as defined in Fig. 4.
