Extended Data Fig. 9: The CNV landscapes of human early embryos by the DNA methylome dataset.
From: Reconstituting the transcriptome and DNA methylome landscapes of human implantation
a, The CNVs for each individual cell at different developmental stages. Red represents duplication, blue represents deletion and white represents diploid. b, Representative examples of euploid and aneuploid single-cell samples. Abnormal copy numbers are highlighted in red (duplication) or blue (deletion). c, The number of cells with CNVs for each chromosome. d, The global DNA methylation levels for euploid and aneuploid cells. Black lines indicate median values, the boxes range from the 25th to 75th percentiles and the whiskers correspond to 1.5× the IQR. EPI, n = 61 cells (euploid, n = 31; aneuploidy, n = 30); PE, n = 84 cells (euploid, n = 45; aneuploidy, n = 39); TE, n = 141 cells (euploid, n = 54; aneuploidy, n = 87) (see details in Supplementary Table 1).
