Extended Data Fig. 8: SCN ablation shapes intestinal ILC3s.
From: Light-entrained and brain-tuned circadian circuits regulate ILC3s and gut homeostasis
a, Circadian clock gene expression in small intestinal lamina propria ILC3s. n = 2 or 3. b, Magnetic resonance imaging of sham and SCN-ablated Per1Venus mice. Sagittal slices. White arrows show SCN ablation. c, Rhythms of animal locomotor activity. Total distance travelled in metres. d, Nissl staining of coronal brain sections. Scale bars: 1 mm (top); 250 μm (bottom). n represents biologically independent animals. Data shown as mean ± s.e.m. Cosinor regression was used to define circadian rhythmicity; cosine fitted curves are shown; standard errors with 95% confidence limits for amplitude and acrophase were extracted from the model and compared using two-tailed Student’s t-test. *P < 0.05; NS, not significant.
