Extended Data Fig. 9: Major driver events and clinical features of HCC.
From: The U1 spliceosomal RNA is recurrently mutated in multiple cancers
Left, this oncoprint shows 15 major driver alterations across all whole-genome-sequenced samples from two HCC projects: LIHC-US (n = 53) and LIRI-JP (n = 129). Project code, gender, risk factor status (heavy alcohol use, or infection with hepatitis B or C virus) and U1 g.3A>C status are shown on the top. White colour in top annotations indicates that data are not available. Right, bar plot shows q values from Cochran–Mantel–Haenszel χ2 tests that compare each alteration with the U1 mutation. Three types of alterations are used in the plot: simple somatic mutations (SSM), structural variations (SV) and somatic copy-number alterations (SCNA).
