Extended Data Fig. 6: PET–CT and biochemical analysis of KL tumours.
From: In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer
a, Crystal structure of complex I (PDB accession 5lc5), with NDUFS1 and NDUFV1 subunits in red, and FeS clusters in yellow.b–d, PET–CT images from three KL mice that were imaged on sequential days with 18F-BnTP (top) and 18F-FDG (bottom). Tumours are circled. Maximum uptake value for each tumour after normalization to maximum uptake of the heart is indicated. e, Western blot analysis from lung nodules that were isolated from mice imaged in b–d. Two lung tumours from mouse 5372 (imaged in b) are shown—T1 in blue (low 18F-FDG and GLUT1 levels; high 18F-BnTP, NDUFS1 and NDUFV1 levels); and T2 in red (high 18F-FDG and GLUT1 levels; low 18F-BnTP, NDUFS1 and NDUFV1 levels). Experiments in b–d are representative of three independent mouse experiments. Experiment in e was performed once.
