Extended Data Fig. 8: Sensitivity of mouse and human lung cancer cell lines to complex I inhibitors phenformin and IACS-010759.
From: In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer
a, TMRE measurement as determined by flow cytometry comparing mouse ADC (n = 3 biological replicates) and mouse SCC (n = 3 biological replicates) cell lines. b, Cell viability of mouse ADC (n = 3 biological replicates) and mouse SCC (n = 3 biological replicates) cells was measured in the presence of indicated concentrations of phenformin for 48 h. c, Cell viability of human ADC (A549; n = 3 biological replicates) and human SCC (RH2; n = 3 biological replicates) cells was measured in the presence of indicated concentrations of phenformin for 48 h. d, Cell viability of human ADC (A549; n = 3 biological replicates) and human SCC (RH2; n = 3 biological replicates) cells was measured in the presence of indicated concentrations of IACS-010759 for 48 h. Data are mean ± s.d. P values determined by unpaired two-tailed t-test or one-way ANOVA (for b–d). Experiments were repeated twice with similar results.
