Extended Data Table 1 Structural mapping of disease-related mutations identified in human T-type VGCC

From: Cryo-EM structures of apo and antagonist-bound human Cav3.1

  1. The mutations are summarized from https://www.uniprot.org/uniprot/O43497, https://www.uniprot.org/uniprot/O95180 and references65,66,67,68,69,70,71,72,73,74. UNIPROT number: Cav3.1, O43497-9; Cav3.2, O95180-1. SCA42, spinocerebellar ataxia 42; SCA42ND, spinocerebellar ataxia 42, early-onset, severe, with neurodevelopmental deficits; HALD4, hyperaldosteronism, familial, 4. The mutations that can be structurally mapped are shaded by light colours coded for disease types.
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