Extended Data Table 2 Activation, steady-state inactivation and conductance parameters of Cav3.1 variants transiently expressed in HEK293T cells

From: Cryo-EM structures of apo and antagonist-bound human Cav3.1

  1. In the comparison of Cav3.1-WT with Cav3.1-Δ8b, ** (red) P < 0.01 versus WT, *** (red) P < 0.001 versus WT. In the comparison of Cav3.1-Δ8b with Cav3.1-Δ8b (K1462G) and Cav3.1-Δ8b (K1462F), **P < 0.01 versus Cav3.1-Δ8b, ***P < 0.001 versus Cav3.1-Δ8b. Each data point represents mean ± s.e.m. (standard deviation of mean). n indicates the number of independent cells. The extra sum-of-squares F test was used to compare the V1/2 of activation and inactivation and Gtop of conductance fits. τinac values of Cav3.1-∆8b, Cav3.1-∆8b (K1462G) and Cav3.1-∆8b (K1462F) were compared by one-way ANOVA and Tukey’s test. The data were analysed using Prism 8.2.1 (GraphPad Software).
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