Extended Data Fig. 8: Comparisons and enrichments between classifications.

a, b, Bubble plots visualizing the overlap between SCP subgroups of breast cancer (SCP1, n = 17; SCP2, n = 21; SCP3, n = 20; SCP4, n = 12; SCP5, n = 32; SCP6, n = 10; SCP7, n = 13; SCP8, n = 11; SCP9, n = 20; SCP10, n = 24; SCP11, n = 31; SCP12, n = 14; SCP13, n = 15; SCP14, n = 11; SCP15, n = 8; SCP16, n = 10; SCP17, n = 9 (SCP18, n = 3 excluded)) and clinical subtypes (a) (HR⁺HER2⁻, n = 173; HR⁺HER2⁺, n = 29; HR⁻HER2⁺, n = 23; triple negative (HR⁻HER2⁻), n = 48) and stromal environments (b) (SE1, n = 49; SE2, n = 88; SE3, n = 9; SE4, n = 24; SE5, n = 25; SE6, n = 24; SE7, n = 8; SE8, n = 14; SE9, n = 14; SE10, n = 18; SE11, n = 2). •P < 0.1, *P < 0.05, **P < 0.01, ***P < 0.001 (one-sided Fisher’s exact test for enrichment.). Exact P values for highlighted pairs: SE1 and SCP7, P = 0.013; SE3 and SCP8, P = 0.021; SE5 and SCP15, P = 0.031; SE6 and SCP3, P = 0.034; SE8 and SCP14, P = 0.008; SE8 and SCP8, P = 0.093; SE9 and SCP12, P = 0.036; HR⁺HER2⁻ and SCP3, P = 0.079; HR⁺HER2⁻ and SCP5, P = 3.58 × 10⁻⁴; HR⁺HER2⁺ and SCP2, P = 0.032; HR⁻HER2⁺ and SCP11, P = 2.36 × 10⁻⁴; HR⁻HER2⁻ and SCP8, P = 0.060; HR⁻HER2⁻ and SCP14, P = 0.008; HR⁻HER2⁻ and SCP15, P = 6.13× 10⁻⁶; HR⁻HER2⁻ and SCP16, P = 0.031.