Extended Data Fig. 1: Expanded CAMERA dataset.
From: GDF15 mediates the effects of metformin on body weight and energy balance
a, Linear association between change in body weight and change in plasma GDF15 between 0 and 18 months among metformin-treated participants (n = 74, Spearman correlation r = –0.26, two-sided P = 0.024). The red line is the linear regression slope, and grey area is 95% CI for the slope. b, Absolute and relative differences in plasma GDF15 concentration between metformin and placebo groups at each time point (total 625 observations in 173 participants). c, d, Individual measures of plasma GDF15 levels in placebo group (c) and metformin group (d) over time. e, Plasma GDF15 concentration (95% CI) in overweight or obese non-diabetic participants with known cardiovascular disease randomized to metformin or placebo in CAMERA; modelled using a mixed linear model as per Fig. 1 and grouped as ‘all participants’ and ‘all participants not reporting diarrhoea and vomiting’. Model includes all participants.
