Extended Data Fig. 2: Effect of single oral dose of metformin in chow-fed mice.
From: GDF15 mediates the effects of metformin on body weight and energy balance
Serum GDF15 levels in male mice measured 2, 4 or 8 h after a single gavage dose of metformin (300 mg kg−1). a, Mice fed ad libitum overnight before gavage. b, Mice fasted for 12 h before gavage. Data are mean ± s.e.m. (a; n = 6 per group, b; n = 4 per group); P values by two-way ANOVA with Tukey’s correction for multiple comparisons.
