Extended Data Fig. 3: Deletion of LATS1/2 inhibits growth of ER+ breast cancer cells.
From: Hippo signalling maintains ER expression and ER+ breast cancer growth
a, Image representative of six biologically independent xenografts for Fig. 2h. Scale bar, 10 mm. b–d, LATS1/2 deficiency inhibits tumour cell proliferation and promotes apoptosis in vivo. Representative images (b) and analysis (c, d) of ERα, phosphorylated histone H3 (S10) and cleaved caspase 3 immunostaining in LATS1/2-deficient and wild-type MCF-7 xenografts. Scale bar, 100 μm. Box plots indicate median and interquartile range.
