Extended Data Fig. 2: Phenotypic changes to CD4+ T cells after intervention.
From: Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells
Longitudinal flow cytometry analysis after treatment with only N-803 (green, n = 7 macaques), only CD8 depletion (blue, n = 14 macaques) and after CD8 depletion and treatment with N-803 (red, n = 14 macaques). a, CD4+ T cell frequency. b–f, Percentage of naive (b), stem cell memory (SCM) (c), central memory (CM) (d), transitional memory (TM) (e) and effector memory (EM) (f) CD4+ T cells. g–l, Percentage of bulk CD4+ T cells that express PD-1 (g), CD25 (h), CD69 (i), HLA-DR (j), CCR5 (k) and both CCR5 and Ki-67 (l). m–v, CCR5 (m–q) and Ki-67 (r–v) expression in different subsets of CD4+ T cells. Data are mean ± s.e.m. Two-sided Kruskal–Wallis tests were used to compare values after the intervention to the pre-intervention baseline and approximate P-value summaries are provided.
