Extended Data Fig. 5: Level of virus reactivation correlated with the absence of CD8+ T cells.
From: Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells
a, b, Correlation between CD8+ T cell counts and viral load (SIV RNA copies per ml of plasma) on day 0, day 3, and weekly up to week 6 after interventions. a, CD8 depletion alone (n = 103 samples from 14 macaques). b, CD8 depletion combined with N-803 treatment (n = 112 samples from 14 macaques). c, d, The area under the curve (AUC) and the average pre-intervention viral load after CD8 depletion alone (c; n = 14 macaques) or CD8 depletion with N-803 treatment (d; n = 14 macaques). Correlation coefficients are calculated using the Spearman’s rank-order correlation (two-tailed, no adjustments). e–g, Longitudinal viral loads (top) and CD8+ T cell counts (bottom) after N-803 treatment alone (e; n = 7 macaques), CD8 depletion alone (f; n = 14 macaques) or CD8 depletion combined with N-803 treatment (g; n = 14 macaques). Colour keys along the bottom indicate animal IDs.
