Extended Data Fig. 8: Transcriptional programs promoted by HLA-DQ8, IL-15 and gluten.

a, b, We contrasted the enrichment scores in the epithelium and the lamina propria for DQ8-D^d-villin-IL-15tg (x axis) and DQ8 (y axis) mice for all pathways enriched at an FDR < 5% in at least one of the strains. Positive or negative scores represent enrichments among genes that are more highly or lowly expressed in gluten-fed mice, respectively. The bottom right quadrant refers to pathways that in response to gluten are upregulated in DQ8-D^d-villin-IL-15tg but downregulated in DQ8 mice. c, Gene Ontology terms significantly enriched among genes differently expressed in response to gluten challenge in DQ8, D^d-villin-IL-15tg and DQ8-D^d-villin-IL-15tg mice. d, Heat map of genes showing a stronger response to gluten in DQ8-D^d-villin-IL-15tg mice as compared to DQ8 and D^d-villin-IL-15tg mice. The colours reflect the magnitude of the response to gluten (log₂-transformed scale), and the stars highlight Gene Ontology terms associated with each of the genes plotted.