Extended Data Fig. 9: Extensive co-associations between CAPs.

a, Example of genomic site with many associated CAPs. Each track shows aligned ChIP–seq reads, and is slightly offset to better show peaks for each experiment. b, Enrichment of biological pathways at HOT regions near enhancers or promoters; P represents sample frequency probability. c, Increasing numbers of CAPs bound at genomic sites correlate with increased evolutionary constraint as measured by GERP, showing incremental fraction overlap of highly constrained elements with CAP-associated sites for both promoter regions (red) and enhancer regions (orange). Boxes, quartiles; centre line, median; whiskers, 1.5 × IQR. d, Increasing numbers of CAPs bound at genomic sites (<2 kb in size) are associated with decreasing distance to nearest TSS; boxes, middle two quartiles; centre line, median; whiskers, 1.5 × IQR. e, Increasing numbers of CAPs bound at genomic sites (<2 kb in size) are associated with increasing expression of nearest gene; boxes, middle two quartiles; centre line, median; whiskers, 1.5 × IQR. d, e, Left to right: n(1) = 124,074, n(2) = 59,407, n(3) = 19,661, n(4) = 12,433, n(5–9) = 23,517, n(10–19) = 14,757, n(20–29) = 7,077, n(30–39) = 4,703, n(40–49) = 3,542, n(50–69) = 5,061, n(70–99) = 4,655, n(>100) = 3,219, total n = 282,105.