Extended Data Fig. 11: SVM and motif analyses in HOT sites.
From: Occupancy maps of 208 chromatin-associated proteins in one human cell type
a, Number of sites (y-axis) by measured number of TFs (x-axis) with classifier values in the top 5% of all classifier values (blue) or with classifier values in the bottom 75% of all classifier values (red) in highly bound regions, based on SVM scores of factor peaks associated with highly bound regions. b, Number of sites (y-axis) by measured number of TFs (x-axis) with classifier values in the top 5% of all classifier values (blue) or with classifier values in the bottom 75% of all classifier values (red), in HOT sites with >70 associated TFs. c, Number of sites (y-axis) by measured number of TFs (x-axis) with classifier values in the top 5% of all classifier values (blue) or with classifier values in the bottom 75% of all classifier values (red), in sites with 2–10 associated TFs. d, Number of sites (y-axis) by measured number of TFs (x-axis) with classifier values in the top 5% of all classifier values (blue) or with classifier values in the bottom 75% of all classifier values (red), in a random set of enhancers with any number of associated TFs (0+). e, Degree of motif enrichment in highly bound regions for all HepG2-expressed TFs with available motifs (n = 365) for top three motifs enriched in highly bound sites with 50+ CAPs (highest P = 3.9 × 10−146). f, Degree of motif enrichment in highly bound regions for all HepG2-expressed TFs with available motifs (n = 365) for top three motifs in enhancers with 2–10 CAPs (highest P = 1.8 × 10−17). g, Degree of motif enrichment in highly bound regions for all HepG2-expressed TFs with available motifs (n = 365) for top motif in random genome enhancers with 0+ CAPs (highest P = 6.9 × 10−3). h, Distribution of all SVM scores (y-axis) for HOT sites with >70 associated CAPs (red), for sites with 2–10 associated CAPs (green), and for random enhancer sites with 0+ CAPs (blue). i, Pie chart showing fraction of HOT sites in which each TF has the highest SVM classifier value, indicating the strongest motif present.
