Extended Data Fig. 2: Unique negative regulators of CHOPNeon across genetic screens.
From: A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol
a–c, Data from Fig. 1a, b and Extended Data Fig. 1f, with statistical significance of mutation enrichment assessed and visualized in the same way. Genes that were identified as significant negative regulators (two-sided Fisher’s exact test, Padj < 0.05) and which had a mutation ratio higher than 4 in the query dataset but not in either of the other two datasets are highlighted in red: CCCP versus tunicamycin and CDDO (a); tunicamycin versus CDDO and CCCP (b); CDDO versus CCCP and tunicamycin (c). ATP5B is also known as ATP5F1B; ATP5F1 as ATP5PB; ATP5O as ATP5PO; GNB2L1 as RACK1; C2orf29 as CNOT11; HIST1H4D as H4C4; and ICT1 as MRPL58.
