Extended Data Fig. 3: Unique positive regulators of CHOPNeon across genetic screens.
From: A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol
a–c, Data from Fig. 1a, b and Extended Data Fig. 1f, with statistical significance of mutation enrichment assessed and visualized in the same way. Genes that were identified as significant positive regulators (two-sided Fisher’s exact test, Padj < 0.05) and which had a mutation ratio lower than 0.25 in the query dataset but not in either of the other two datasets are highlighted in red: CCCP versus tunicamycin and CDDO (a); tunicamycin versus CDDO and CCCP (b); CDDO versus CCCP and tunicamycin (c). ATPIF1 is also known as ATP5IF1; KIAA0141 is also known as DELE1; KIAA0664 is also known as CLUH; TH1L is also known as NELFCD; C11orf73 is also known as HIKESHI; C22orf29 is also known as RTL10; H2AFZ is also known as H2AZ1.
