Extended Data Fig. 4: Overview of positive and negative regulators of CHOPNeon after treatment with different drugs.
From: A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol
a–c, Data from Fig. 1a, b and Extended Data Fig. 1f, with statistical significance of mutation enrichment assessed and visualized in the same way. For all datasets, significant positive regulators (two-sided Fisher’s exact test, Padj < 0.05) with a mutation ratio lower than 0.25 (corresponding to an effect size of 4× or greater) are shown in blue, whereas significant negative regulators (two-sided Fisher’s exact test, Padj < 0.05) with a mutation ratio higher than 4 are shown in yellow.
