Fig. 4: Association between RBP binding and RNA expression upon knockdown.
From: A large-scale binding and functional map of human RNA-binding proteins
a, Heatmap indicates significance of overlap between genes with regions that were significantly enriched (P ≤ 10−5 and ≥4-fold enriched in eCLIP versus input) and genes that were significantly (top) increased or (bottom) decreased (P < 0.05 and false discovery rate (FDR) <0.05) in RBP knockdown RNA-seq experiments. Significance determined by two-sided Fisher’s exact test or Yates’ χ2 approximation where appropriate; *P < 0.05, **P < 10−5 after Bonferroni correction. Shown are all overlaps meeting a P < 0.05 threshold; see Extended Data Fig. 5b for all comparisons. b, c, Lines indicate cumulative distribution plots of gene expression fold-change (knockdown versus control) for indicated categories of eCLIP enrichment of DDX6 in HepG2 cells (b), and IGF2BP3 in HepG2 cells (c). **P < 10−5, *P < 0.05; two-sided Kolmogorov–Smirnov test.
