Extended Data Fig. 2: Generalization of cues after reward conditioning and SCH23390 effects.
From: Dopamine D2 receptors in discrimination learning and spine enlargement
a, Schematic of tone–reward classical conditioning task in classical conditioning in head-restrained mice. A tube monitored licking responses. b, Raster plots of licking responses before (left), during (middle) and after (right) conditioning in a representative mouse. Grey shading indicates the periods of CS presentation. c–f, Generalization to pure tones (c, d), and light (e, f). PSTHs in c, e show licking responses before (left), during (middle) and after (right) conditioning. Lick scores are plotted against time (d, f). n = 11 (c, d) and 7 mice (e, f). g, Schematic of drug infusion into the bilateral NAc. h, i, Effect of drug infusion on generalized conditioned responses. Top, plots of lick scores; bottom, PSTHs at generalization tests. Grey shading indicates periods of CS presentation. Black and red bars indicate infusion periods. n = 6 (h) and 6 mice (i). Error bars and shading indicate s.e.m. Vertical grey shading in c, e, h, i indicates CS periods. Samples of mice are biological replicates.
