Extended Data Fig. 5: Molecular features of ELP1-associated MB.
From: Germline Elongator mutations in Sonic Hedgehog medulloblastoma
a, Expression of ELP1 stratified by consensus medulloblastoma subgroup (n = 208 patients). P value was calculated using likelihood ratio tests. b, Expression of ELP1 stratified by molecular MBSHH subtype (n = 90 patients). P value was calculated using likelihood ratio tests. c, Expression of ELP1 stratified by germline ELP1 mutation status (n = 90 patients). P value was calculated using likelihood ratio tests. d, Differential gene expression in mutant (n = 10) and wild-type (n = 9) ELP1 SHHα. P values were derived from models that use negative binomial test statistics and were adjusted for multiple testing based on FDR correction. e, Functional gene enrichment in ELP1-associated SHHα. f, GSEA-based enrichment of UPR pathways in MBSHH proteomes. **P < 0.01, ns (not significant), P > 0.05, two-sided Mann–Whitney U-test. g, GSEA-based enrichment of the Elongator complex in MBSHH proteomes. ***P < 0.001, two-sided Mann–Whitney U-test. All box plots are as defined in Fig. 1g.
