Extended Data Fig. 4: Transplanted CiPCs express photoreceptor-specific markers and connected to the inner retina three months after transplantation.
From: Pharmacologic fibroblast reprogramming into photoreceptors restores vision
a, Expression of recoverin (Recov, red) in CiPCs (green). b, Expression of rhodopsin (Rho, red) in GFP-expressing CiPCs. c, Expression of rod ribbon-synapse protein ribeye (red) in transplanted CiPCs (green). The bottom panel shows a magnified version of the image (arrowhead). d, Close apposition of transplanted CiPCs (green) with PKC-positive (red) rod bipolar cells (white arrowhead). e, Expression of synaptic marker protein synaptophysin (red, arrowhead) in transplanted CiPCs (green) (co-localization, yellow). d, e, Left, images at 20× magnification; right, images at higher digital magnification. In a–e, experiments were repeated twice with similar results. Scale bars, 10 μm.
