Extended Data Fig. 4: Cinanserin is an inhibitor of SARS-CoV-2 Mpro.
From: Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
a, The docking result of cinanserin. The structure of SARS-CoV-2 Mpro is shown as a white cartoon, cinanserin is shown as cyan balls and sticks, and residues predicted to be interacting with cinanserin are shown as sticks. b, Inhibitory activity of cinanserin on Mpro. c, Antiviral activity of cinanserin determined by qRT–PCR. d, Cytotoxicity assay of cinanserin on Vero E6 cells. All data are shown as mean ± s.e.m., n = 3 biological replicates.
