Extended Data Fig. 6: Autoimmune inflammation in T_reg-specific Usp22 knockout mice.

a, Body weight differences between 8-week-old, sex-matched C57BL/6 WT (BL6), Usp22^+/+Foxp3^YFP-cre WT or Usp22^fl/flFoxp3^YFP-cre KO mice. b, Representative flow cytometry analysis of CD44 and CD62L expression in splenic CD4⁺ and CD8⁺ T cells from aged seven-month-old Usp22^+/+Foxp3^YFP-cre WT and Usp22^fl/flFoxp3^YFP-cre KO mice. Numbers in quadrants indicate percentage of each cell population. c, The frequency of splenic CD4⁺ and CD8⁺ effector T cells (CD44^highCD62L^low) and naive T cells (CD44^lowCD62L^high) of aged seven-month-old Usp22^+/+Foxp3^YFP-cre WT and Usp22^fl/flFoxp3^YFP-cre KO mice summarized, corresponding to b. All data are presented as mean ± s.e.m. Sample sizes (n), P values, statistical tests and number of times experiments were replicated are listed in Methods, ‘Statistics and reproducibility’.

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