Extended Data Fig. 1: Regional BBB Ktrans constant in eight additional brain regions in APOE4 carriers and non-carriers (APOE3) with CDR status 0 and 0.5.
From: APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline
BBB Ktrans constant in the ITG (a), superior frontal gyrus (SFG, b), caudate nucleus (CN, c), thalamus (Thal, d), striatum (Str, e), subcortical watershed normal-appearing white matter (Subcort. WS NAWM, f), corpus callosum (CC, g), and internal capsule (IC, h) in individuals with CDR 0 bearing APOE3 (black, n = 128) and APOE4 (red, n = 68), and with CDR 0.5 bearing APOE3 (black, n = 14) and APOE4 (red, n = 25). Continuous lines, median; dotted lines, IQR. Significance by ANCOVAs for main effects and post hoc comparisons controlling for age, sex, and education.
