Extended Data Fig. 3: Regional BBB Ktrans constant in eight additional brain regions in APOE4 carriers and APOE3 carriers with different degrees of cognitive domain impairment.
From: APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline
Ktrans constant in the ITG (a), SFG (b), CN (c), thalamus (d), striatum (e), subcortical WS NAWM (f), CC (g), and IC (h) in individuals with no cognitive domains impaired bearing APOE3 (black, n = 70) or APOE4 (red, n = 40): one cognitive domain impaired bearing APOE3 (n = 18) or APOE4 (n = 21); and two or more cognitive domains impaired bearing APOE3 (n = 7) or APOE4 (n = 12). Continuous lines, median; dotted lines, IQR. Significance tests from ANCOVAs for main effects and post hoc comparisons controlling for age, sex, and education.
