Extended Data Fig. 4: Regional BBB Ktrans constant in all studied brain regions in APOE4 carriers and APOE3 carriers in relation to vascular risk factors.
From: APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline
Ktrans constant in the HC (a), PHG (b), ITG (c), SFG (d), CN (e), thalamus (f), striatum (g), subcortical WS NAWM (h), CC (i), and IC (j) in APOE3 (green, n = 80) and APOE4 (brown, n = 42) carriers with 0–1 vascular risk factors (VRFs), and APOE3 (n = 58) and APOE4 (n = 51) carriers with 2+ VRFs. Continuous lines, medians; dotted lines, IQR. Significance by ANCOVAs for main effects and post hoc comparisons controlling for age, sex, and education.
