Fig. 1: pLoF constraint in drug targets.
From: Evaluating drug targets through human loss-of-function genetic variation
a, Histogram of pLoF obs/exp values for all genes (black, n = 17,604) versus drug targets (blue, n = 383). b, Forest plot of means (dots) and 95% confidence intervals of the mean (line segments), for constraint in the indicated gene sets (data sources and n values in Extended Data Table 1). For drug effect, ‘positive’ indicates agonist, activator or inducer, whereas negative indicates antagonist, inhibitor or suppressor, for example. c, Examples of drug targets and corresponding drug classes from across the constraint spectrum. Details in Extended Data Table 2.
