Extended Data Fig. 7: Systemic inflammation and its relation to enterotypes and to BMI in the non-statin-medicated BMIS cohort.
From: Statin therapy is associated with lower prevalence of gut microbiota dysbiosis
a, Individuals with faecal samples enterotyped as Bact2 displayed more pronounced systemic inflammation levels as assessed through fasting serum hsCRP concentrations when compared with participants classified as Rum, Prev and Bact1 (n = 763 biologically independent samples, Kruskal–Wallis P = 1.37 × 10−10; Rum = Bact1 < Prev < Bact2; different letters denote enterotypes with a significant pairwise difference (post hoc Dunn tests provided in Supplementary Table 13)). The body of the box plot represents the first and third quartiles of the distribution, the line represents the median, and the whiskers extend from the quartiles to the last data point within 1.5× IQR, with outliers beyond. b, Linear model of the correlation between host systemic inflammation (hsCRP concentration, log10-transformed) and BMI, fitted by least squares regression (n = 763 biologically independent samples; estimated intercept = −0.8681, estimated slope = 0.0379, R2 = 0.47, P = 1.5 × 10−108).
