Extended Data Fig. 2: The association of BMI, fat mass percentage and serum fasting triglyceride levels with faecal microbial gene richness and faecal microbial load in the non-statin-medicated BMIS cohort (n = 782 participants).
From: Statin therapy is associated with lower prevalence of gut microbiota dysbiosis
All three covariates were found to be associated with both microbiome gene richness (n = 711 biologically independent samples, Spearman’s ρ = −0.45 to −0.26, Padj = 4.0 × 10−39 to 1.6 × 10−13), a proxy for microbial biodiversity previously suggested as a marker of metabolic health in obese individuals8, and faecal microbial load (n = 711 biologically independent samples, Spearman’s ρ = −0.17 to −0.13, Padj = 4.1 × 10−6 to 3.1 × 10−4; Supplementary Table 7). Adjustment for multiple testing (Padj) was performed using the Benjamini–Hochberg method. Least square linear regression lines (dashed line) with 95% confidence interval (grey shading) are provided for visual representation of the non-parametric testing provided in Supplementary Table 7. Data points are coloured by enterotype classification.
