Extended Data Fig. 6: Relationships between sex bias of disease associations and LD to C4 risk for variants in the MHC region.

a, Relationship between male bias in SLE risk (difference between male and female log–odds ratios) and LD with C4 risk for common (minor allele frequency (MAF) > 0.1) genetic markers across the extended MHC region (6,748 cases and 11,516 controls). For each SNP, the allele for which sex risk bias is plotted is the allele that is positively correlated (via LD) with C4-derived risk score. b, Relationship between male bias in Sjögren’s syndrome risk (log-odds ratios) and LD with C4 risk for common (MAF > 0.1) genetic markers across the extended MHC region (673 cases and 1,153 controls). For each SNP, the allele for which sex risk bias is plotted is the allele that is positively correlated (via LD) with C4-derived risk score. c, Relationship of male bias in schizophrenia risk (log odds ratios) and LD to C4A expression for common (MAF >0.1) genetic markers across the extended MHC region (28,799 cases and 35,986 controls). For each SNP, the allele for which sex risk bias is plotted is the allele that is positively correlated (via LD) with imputed C4A expression, as previously described⁷.