Extended Data Fig. 8: Immunohistochemical staining of fibrillin 1.
From: A positively selected FBN1 missense variant reduces height in Peruvian individuals
a, b, Fibrillin 1 staining of skin biopsies from two individuals with the rs200342067 C/C genotype. c, d, Fibrillin 1 staining of skin biopsies from two individuals with the T/T genotype matched for age, sex and ancestry proportions. Individuals with the C/C genotype have less fibrillin 1 deposition in the dermal extracellular matrix and shorter microfibrillar projections from the dermal–epidermal junction into the superficial (papillary) dermis (red arrows, 20×) as well as less fibrillin 1 deposition in the deeper dermis. Two magnification are shown, the red rectangles in the first column (20× magnification) are magnified in the second column (60×).
