Extended Data Fig. 1: Peruvian population structure.
From: A positively selected FBN1 missense variant reduces height in Peruvian individuals
a, b, PCA of genotyping data from Peruvian individuals included in this study (n = 3,134 individuals) merged with the data from continental populations from phase 3 of the 1000 Genomes Project (n = 3,469 individuals) as well as the data from Siberian and Native American populations from the previously published study52 (n = 738 individuals), which were used as a reference panel (number of variants, 34,936). Dots, individuals; colour, populations (AFR, African; AMR, South American; EAS, east Asian; SAS, south Asian; EUR, European; SIB, Siberian; NAT, Native American). c, Global ancestry analysis using ADMIXTURE (K = 4). We observed varying levels of European, African and Asian admixture in our cohort (n = 3,134 individuals) with a median proportion of Native American, European, African and Asian ancestry per individual of 0.83 (IQR = 0.72–0.91), 0.14 (0.08–0.21), 0.01 (0.003–0.03) and 0.003 (10−5–0.01), respectively. Vertical lines, individuals; colours, genomic proportion of a given ancestry in the genome of each individual. ADMIXTURE analysis (K = 4) is done using all populations in phase 3 of the 1000 Genomes Project as well as the Siberian and Native American populations from the previously published study52, which were used as a reference. African (AFR) ancestry includes Yoruba in Ibadan, Nigeria, Luhya in Webuye, Kenya, Gambian in Western Divisions in the Gambia, Mende in Sierra Leone, Esan in Nigeria, Americans of African Ancestry in southwest United States. European (EUR) ancestry includes central European, Utah residents (CEPH) with northern and western European ancestry (USA), Toscani in Italy, Finnish in Finland, British in England and Scotland, Iberian population in Spain. East Asian (EAS) ancestry includes Han Chinese in Beijing, China, Japanese in Tokyo, Japan, Southern Han Chinese, Chinese Dai in Xishuangbanna, China, Kinh in Ho Chi Minh City, Vietnam. South Asian (SAS) ancestry includes Gujarati Indian from Houston, Texas (USA), Punjabi from Lahore, Pakistan, Bengali from Bangladesh, Sri Lankan Tamil from the United Kingdom, Indian Telugu from the United Kingdom. Puerto Ricans (PUR) from Puerto Rico. Colombians (CLM) from Medellin, Colombia. Mexicans (MXL) from Los Angeles, California (USA). Peruvian individuals (PEL) from Lima, Peru. Altic, Altaic language family, which includes Yakut, Buryat, Evenki, Tuvinians, Altaian, Mongolian, Dolgan. North Amerind, northern Amerindian language family, which includes Maya, Mixe, Kaqchikel, Algonquin, Ojibwa and Cree. Central Amerind, central Amerindian language family, which includes Pima, Chorotega, Tepehuano, Zapotec, Mixtec and Yaqui. Andean, Andean language family, which includes Quechua, Aymara, Inga, Chilote, Diaguita, Chono, Hulliche and Yaghan. A full list of all populations in all language groups has been published previously52.
