Extended Data Fig. 2: Association of rs200342067 and height.
From: A positively selected FBN1 missense variant reduces height in Peruvian individuals
a, Single-variant association analysis (n = 3,134 individuals and 7,756,401 variants). Dotted red line, genome-wide significance threshold of 5 × 10−8. Five SNPs that overlap the coding sequence of FBN1 passed the genome-wide significance threshold. We did not observe any inflation in test statistics (λ = 1.02). Association P values are from two-sided Wald tests. b, rs200342067 in heterozygous individuals reduces height by 2.2 cm (4.4 cm in homozygous individuals, including 11 individuals with the C/C genotype, 275 the C/T genotype and 2,848 the T/T genotype) and could explain 0.9% of the phenotypic variance in height in our cohort (n = 3,143 individuals). The x axis shows the rs200342067 genotype; the y axis shows the height residuals after adjustments for age, sex and a GRM as random effect.
