Extended Data Fig. 5: Developmental trajectory of YSMP in human embryonic liver.
From: Deciphering human macrophage development at single-cell resolution
a, PCA of YSMP, GMP, myeloblast and monocyte populations sampled from CS12 to CS17 livers using PC1 and PC2 (n = 4 biologically independent embryo samples and 88 cells). b, PCA matrix of YSMP, GMP, myeloblast and monocyte populations. c, Monocle visualization of YSMP, GMP, myeloblast and monocyte populations sampled from CS12 to CS17 livers with the expression of the indicated genes mapped on. d, Heat map showing scaled expression of branching curated genes of monocyte and neutrophil fates ordered by pseudotime. e, Six main patterns of gene expression compared between YSMP, GMP, myeloblast and monocyte clusters. The expression levels of all pattern genes (coloured lines) and the average expression of each pattern (black line) are shown. The complete list of genes can be found in Supplementary Table 5. f, g, Heat maps displaying expression of monocyte specification-related surface markers (f) and transcription factors (g) along pseudotime.
