Extended Data Fig. 5: Crystal structure of Ago2 overlaid with REMD ensembles.
From: Base-pair conformational switch modulates miR-34a targeting of Sirt1 mRNA
Superposition of ground state (green) and excited state (orange) conformational ensembles on the Ago2 crystal structure (PDB code 4W5T), with seed sequences aligned to crystallographic miRNA–mRNA positions (red). Although the seed orientations are comparable, the ground-state and excited-state conformations sample different space within Ago2.
