Extended Data Fig. 3: CR8-induced degradation of cyclin K is not dependent on a canonical DCAF substrate receptor.
From: The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K
a, Drug sensitivity of K562-Cas9, P31FUJ-Cas9, THP1-Cas9 and MM1S-Cas9 cells that were treated with CR8 for three days (n = 3). b, mRNA levels of genes in the DCAF library. The black vertical lines represent the mean (n = 4). c, Flow analysis of K562-Cas9, P31FUJ-Cas9, THP1-Cas9 and MM1S-Cas9 cells expressing sgRNAs and a BFP marker after a three-day treatment with 1 μM CR8. The black vertical lines represent the mean (n > 2).
