Extended Data Fig. 8: Quantitative analysis of different enzyme classes and functional protein domains across the tree of life.

a, We classified the contribution of peptides to the top 90% of protein mass within all 100 organisms according to the enzyme commission (EC) number, using the Unipept web-tool (https://unipept.ugent.be/). The alluvial plot illustrates the proportions of each enzyme class across all organisms in our study. b, Comparison of the three domains of life with respect to their normalized contribution of peptides to each enzyme class. c, Proteins that contribute to the top 90% of the protein mass within all 100 organisms studied herein were annotated according to their known functional protein domains, and the intensities for different functional domains of an organism were summed to display the most abundant functional protein domains across the tree of life. The intensity is displayed on a log₁₀ scale.