Extended Data Table 1 A lesion segregation-based test for oncogenic selectionA lesion-segregation-based test for oncogenic selection

From: Pervasive lesion segregation shapes cancer genome evolution

  1. Recurrently mutated sites in C3H and CAST tumours with sufficient estimated power to detect oncogenic selection through biased strand retention analysis (required >33 C3H recurrences or >41 CAST recurrences). Odds ratio values >1 indicate the predicted correlation of driver mutation and Watson/Crick strand retention in tumours with the candidate driver mutation, but not for those without the mutation. The Fisher’s exact test was performed on counts of chromosomes with Watson and Crick strand asymmetries (Methods). Each tested site was autosomal, thus total sample sizes were: n = 2 × 371 = 742 for C3H, and n = 2 × 84 = 168 for CAST. P-values (two-sided) are shown after Bonferroni correction (7 tests performed). Known driver indicates the mutation or its orthologous change has previously been implicated as a driver of hepatocellular carcinoma6. The CAST 6:37451282_A/T mutation is orthologous to the C3H 6:37548568_A/T mutation.
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