Extended Data Fig. 4: Clustering motifs by similarity.
From: Global reference mapping of human transcription factor footprints
a, Outline of motif clustering approach. Motif models (n = 2,174) from ref. 11, JASPAR12 (2018), and HOCOMOCO13 were clustered by motif similarity. b, Hierarchically clustered heat map of the pairwise similarity scores between motifs. The cluster dendrogram was cut at height 0.7 to create non-redundant archetypal clusters of motifs. c–f, Exemplar clusters of similar TF recognition sequences corresponding to KLF/SP (C2H2 family), EGR (C2H2 family), MEF2 (MADS) and E-box/CATATG (bHLH).
