Extended Data Fig. 6: Aggregate DNase I cleavage profiles for diverse TFs.
From: Global reference mapping of human transcription factor footprints
a, Physical structure of the paired-box TF PAX6 bound to its cognate recognition element (PDB: 6PAX)24. b–e, Per-nucleotide DNase I cleavage patterns surrounding instances of motifs within genomic footprints for PAX6 (fetal eye) (b); EBF1 (differentiated bipolar neuron) (c); SOX3 (differentiated neuronal cell) (d); and MYF6 (fetal tongue) (e). For each, top left shows a randomly ordered heat map of the per-nucleotide relative DNase I cleavage protection (observed/expected) for each footprinted motif instance (posterior footprint probability >0.99). Below, aggregate DNase I protection averaged over all footprinted sites. Right, DNase I cleavage at individual motif instances (blue, observed cleavage; yellow, expected cleavage).
