Extended Data Fig. 8: Comparative footprinting identifies cell-selective TF occupancy at nucleotide resolution.

a, b, Comparative footprinting within the SCAMP5 (a) and UCP2 (b) promoters identifies footprints that are differentially occupied in nervous cell and tissue types. Top, DNase I cleavage in two exemplar nervous and non-nervous cell types. Bottom, mean differential per nucleotide cleavage (log₂ observed/expected) between nervous system-derived (SCAMP5: n = 26; UCP2: n = 28 out of 31) and non-nervous samples (SCAMP5: n = 151; UCP2: n = 189 out of 212) in which region is DNase I hypersensitive (Supplementary Methods). The colour of each bar indicates the statistical significance (–log₁₀ p) of the per-nucleotide differential test.