Fig. 2: Footprints encapsulate topological structures of individual TF–DNA interactions.
From: Global reference mapping of human transcription factor footprints
a, Structure of CTCF zinc fingers 3–11 bound to cognate DNA recognition sequence (Protein Data Bank (PDB) codes: 5YEF and 5YEL)21. DNA coloration shows mean observed versus expected cleavage at footprinted CTCF motifs (in T regulatory cells). b, Heat map of relative cleavage at each of 25,852 footprinted CTCF motifs (posterior probability >0.99). Below, aggregate (summed) nuclease cleavage relative to footprinted motifs. Right, nuclease cleavage (observed and expected) at three footprints randomly selected across genome. c, Footprint width is tightly correlated with the width of the TF recognition sequence (Spearman’s ρ = 0.9, P = 0.001).
