Fig. 3: Modes of TF occupancy within regulatory DNA.
From: Global reference mapping of human transcription factor footprints
a, Overlap and spatial enrichment of TF recognition sequences within footprints binned by width. Left, density heat map of motif occurrences around footprints binned by width. Right, proportion of footprints uniquely overlapped by 0, 1 or 2 or more recognition sequences. b, Percentage of footprints representing occupancy of single TF (≤30 bp) or multiple TFs (>30 bp). c, d, Footprint density and spacing (edge-to-edge) plotted against mean normalized cleavage density (tags per 150 bp per million reads) within promoter-proximal and distal DHSs. Solid lines and shaded regions indicate median and middle 50th percentile, respectively. e, A typical DHS contains about five or six directly bound TFs spaced roughly 20 bp apart.
