Extended Data Fig. 6: Sequence features of the human monoclonal antibodies used in animal studies and monoclonal antibody pharmacokinetics following their administration to NHPs.
From: Potently neutralizing and protective human antibodies against SARS-CoV-2
a, Sequence features of human monoclonal antibodies tested in animal models. Inferred variable genes are indicated and CDR3 amino acids are shown for heavy and light chains. b, Macaques received one 50 mg kg−1 dose of COV2-2196, COV2-2381 or an isotype control monoclonal antibody (n = 4 macaques per group) intravenously on day −3 and then were challenged intranasally and intratracheally with SARS-CoV-2 at day 0. The concentration of human monoclonal antibodies was determined at indicated time points. Each curve shows an individual macaque. Data represent a single experiment.
